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Increased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Objective: Atherosclerosis is a chronic inflammatory disorder that involves a range of inflammatory mediators. Although interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have examined IL-9 and IL-9 receptor (IL-9R) systemically and locally in patients with coronary and carotid atherosclerosis. Methods: Plasma IL-9 was quantified ...
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)
The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n = 102) was associated ...
Increased secondary/primary bile acid ratio in chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-09)
<p><i>Objective</i> Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis. We aimed to investigate the pattern of BAs, and particularly microbiota-transformed (secondary) BAs, in ...