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Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
<p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p>
<p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...
IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-12)
<p><i>Background</i>: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL-6 receptor (IL-6R)-antagonist tocilizumab on the expression of the ...
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
Aims: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction.
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Methods and results: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary ...
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-13)
INTRODUCTION: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as ...
The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-14)
The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured ...
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and
hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic
process, but earlier research focus on adaptive immunity has gradually switched towards the role of
innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between
them, ...
Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-15)
Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB)
are requested. We have studied biomarkers that may differentiate between active and
latent TB infection (LTBI), the influence of HIV infection and changes during anti-TB chemotherapy.
Methods: Thirty-eight plasma cytokines, assessed by multiplex and enzyme immunoassays,
were analyzed in patients with active TB before ...
Increased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Objective: Atherosclerosis is a chronic inflammatory disorder that involves a range of inflammatory mediators. Although
interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have
examined IL-9 and IL-9 receptor (IL-9R) systemically and locally in patients with coronary and carotid atherosclerosis.
Methods: Plasma IL-9 was quantified ...
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-28)
<p><i>Background</i>: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine ...