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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21–6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we ...
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
<i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p>
<p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p>
<p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
Background - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult ...
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p>
<p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ...
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
Venous thromboembolism is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of venous thromboembolism, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of venous thromboembolism. Cases with incident venous ...
Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE)
events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to
influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single
nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ...
Genetically predicted cortisol levels and risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
Introduction - In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk ...
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
<p><b>Background</b> The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear.
<p><b>Objective</b> To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case–cohort.
<p><b>Methods</b> Cases ...