Søk
Viser treff 1-5 av 5
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-22)
BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND ...
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single
nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the
rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is
causal, one could also expect rs4704397 genotypes to predict CVD and possibly ...
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects,
we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist
circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up
(additional 137,052 individuals) in a total ...
Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromso OGTT Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Hb 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by Hb and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. Hb , fasting ...
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Genome-wide association studies (GWAS) have identified ~ 100 loci associated with blood lipid levels, but much of the trait
heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We
conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with
triglycerides (TG), high-density ...