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Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four
different platforms were ...
Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
High blood concentrations of n-6 fatty acids (FAs) relative to n-3 FAs may lead to a “physiological switch” towards permanent low-grade inflammation, potentially influencing the onset of cardiovascular and inflammatory diseases, as well as cancer. To explore the potential effects of FA ratios prior to disease onset, we measured blood gene expression profiles and plasma FA ratios (linoleic ...
The hazards of death by smoking in middle-aged women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Recent studies have found that the risk of death
continues to increase among female smokers, as compared
with women who have never smoked. We wanted to
examine the effect of smoking on all-cause and causespecific
mortality and calculate the corresponding population
attributable fraction (PAF) of mortality in the Norwegian
women and cancer study; a nationally
representative prospective cohort ...
Overdiagnosis of breast cancer in the Norwegian Breast Cancer Screening Program estimated by the Norwegian Women and Cancer cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifetime outside screening. This analysis compares the cumulative incidence of breast cancer in screened and
unscreened women in Norway from the start of the fully implemented Norwegian ...
Consumption of dairy products and colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of
total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for
individual dairy products with differing fat contents.
Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), ...
Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains
controversial.
Methods: 373,803 subjects aged 25–70 years were recruited in 10 European countries (1992–2000) in the PANACEA project
of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height
were measured at baseline and ...
Plasma 25 hydroxyvitamin D level and blood gene expression profiles: a cross-sectional study of the Norwegian Women and Cancer Post-genome Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-03-06)
Background/Objectives: Vitamin D deficiency has been associated with increased risk of developing several diseases, but
much is unknown about the molecular effects involved. Gene expression technology is increasingly being used to elucidate
molecular mechanisms related to nutritional factors, and in this study of free-living, middle-aged Norwegian women, we aimed
at identifying gene expression ...
Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background
The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.
Methods
Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term ...