Now showing items 1-10 of 17
A comprehensive analysis of the androgen receptor gene and risk of breast cancer. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-20)
Introduction Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer ...
Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia. A meta-analysis of randomized controlled trials
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-11-23)
Extracts of Chinese red yeast rice (RYR, a traditional dietary seasoning of Monascus purpureus) contains several active ingredients including lovastatin, and several trials of its possible lipid-lowering effects have been conducted. This meta-analysis assesses the effectiveness and safety of RYR preparations on lipid modification in primary hyperlipidemia. We included randomized controlled trials ...
Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-05-02)
Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene. The intron (Nae.S516) has a complex organization of two ribozyme domains (NaGIR1 and NaGIR2) and a homing endonuclease gene (NaHEG). NaGIR2 is responsible for intron excision, exon ligation, and full-length intron RNA circularization, ...
Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-03)
Background In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. ...
Measuring extravascular lung water. Animals and humans are not the same
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-07-24)
The evolution of extravascular lung water (EVLW) monitoring is an important step forward in the hemodynamic assessment of critically ill patients.
Circular instead of hierarchical. Methodological principles for the evaluation of complex interventions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-06-24)
Background: The reasoning behind evaluating medical interventions is that a hierarchy of methods exists which successively produce improved and therefore more rigorous evidence based medicine upon which to make clinical decisions. At the foundation of this hierarchy are case studies, retrospective and prospective case series, followed by cohort studies with historical and concomitant non-randomized ...
Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-10-24)
This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional ...
A third approach to gene prediction suggests thousands of additional human transcribed regions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03)
The identification and characterization of the complete ensemble of genes is a main goal of deciphering the digital information stored in the human genome. Many algorithms for computational gene prediction have been described, ultimately derived from two basic concepts: (1) modeling gene structure and (2) recognizing sequence similarity. Successful hybrid methods combining these two concepts have ...
Test-retest reproducibility of a food frequency questionnaire (FFQ) and estimated effects on disease risk in the Norwegian Women and Cancer Study (NOWAC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-01-31)
Background: The Norwegian Women and Cancer Study (NOWAC) is a national population-based cohort study with 102 443 women enrolled at age 30–70 y from 1991 to 1997. The present study was a methodological sub-study to assess the test-retest reproducibility of the NOWAC food frequency questionnaire (FFQ), and to study how measurement errors in the data can affect estimates of disease risk. Methods: A ...
Regression analysis with categorized regression calibrated exposure. Some interesting findings
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-07-04)
Background: Regression calibration as a method for handling measurement error is becoming increasingly well-known and used in epidemiologic research. However, the standard version of the method is not appropriate for exposure analyzed on a categorical (e.g. quintile) scale, an approach commonly used in epidemiologic studies. A tempting solution could then be to use the predicted continuous ...