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Investigations of binding mode for the cyclopentapeptide CXCR4 antagonist FC131 by induced fit docking
(Master thesis; Mastergradsoppgave, 2009-06-12)
The GPCR CXCR4 is a chemokine receptor that by activation of its natural ligand SDF-1Î± is involved in the pathology of several diseases like cancer metastasis, leukemia cell progression and rheumatoid arthritis. The finding that CXCR4 plays a critical role for HIV-1 entry into T cells prompts additional motivation for the design of CXCR4 inhibitor. The establishment of the possible binding mode(s) ...