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Endringer i forskningsaktiviteten ved Universitetssykehuset Nord-Norge 2000 - 2005
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006)
Bakgrunn: Norsk medisinsk forskning hevder seg dårlig i nordisk sammenheng. Ved UniversitetssykehusetNord-Norge (UNN) ble forskningsaktivitet og hindringer for klinisk forskning undersøktmed en spørreskjemaundersøkelse i år 2000. Denne undersøkelsen er nå gjentatt etter fem år for å se omforholdene er endret.Materiale og metode: Alle leger og psykologer ved UNN fikk i mai 2005 tilsendt det samme ...
Plasma levels of leptin and mammographic density among postmenopausal women. A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-29)
Introduction Obesity has been linked to increased risk of breast
cancer in postmenopausal women. Increased peripheral
production of estrogens has been regarded as the main cause
for this association, but other features of increased body fat
mass may also play a part. Leptin is a protein produced mainly
by adipose tissue and may represent a growth factor in cancer.
We examined the association ...
A third approach to gene prediction suggests thousands of additional human transcribed regions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03)
The identification and characterization of the complete ensemble of genes is a main goal of deciphering the digital
information stored in the human genome. Many algorithms for computational gene prediction have been described,
ultimately derived from two basic concepts: (1) modeling gene structure and (2) recognizing sequence similarity.
Successful hybrid methods combining these two concepts have ...
Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-05-02)
Background
Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene. The intron (Nae.S516) has a complex organization of two ribozyme domains (NaGIR1 and NaGIR2) and a homing endonuclease gene (NaHEG). NaGIR2 is responsible for intron excision, exon ligation, and full-length intron RNA circularization, ...
Circular instead of hierarchical. Methodological principles for the evaluation of complex interventions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-06-24)
Background: The reasoning behind evaluating medical interventions is that a hierarchy of
methods exists which successively produce improved and therefore more rigorous evidence based
medicine upon which to make clinical decisions. At the foundation of this hierarchy are case studies,
retrospective and prospective case series, followed by cohort studies with historical and
concomitant non-randomized ...
Test-retest reproducibility of a food frequency questionnaire (FFQ) and estimated effects on disease risk in the Norwegian Women and Cancer Study (NOWAC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-01-31)
Background:
The Norwegian Women and Cancer Study (NOWAC) is a national population-based cohort study with 102 443 women enrolled at age 30–70 y from 1991 to 1997. The present study was a methodological sub-study to assess the test-retest reproducibility of the NOWAC food frequency questionnaire (FFQ), and to study how measurement errors in the data can affect estimates of disease risk.
Methods:
A ...
Regression analysis with categorized regression calibrated exposure. Some interesting findings
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-07-04)
Background: Regression calibration as a method for handling measurement error is becoming
increasingly well-known and used in epidemiologic research. However, the standard version of the
method is not appropriate for exposure analyzed on a categorical (e.g. quintile) scale, an approach
commonly used in epidemiologic studies. A tempting solution could then be to use the predicted
continuous ...
"When patients have cancer, they stop seeing me". The role of the general practitioner in early follow-up of patients with cancer. A qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-21)
Background
The role of the general practitioner (GP) in cancer follow-up is poorly defined. We wanted to describe and analyse the role of the GP during initial follow-up of patients with recently treated cancer, from the perspective of patients, their relatives and their GPs.
Methods
One focus group interview with six GPs from the city of Bodø and individual interviews with 17 GPs from the ...
A comprehensive analysis of the androgen receptor gene and risk of breast cancer. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-20)
Introduction
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer ...
Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-03)
Background
In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. ...