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High expression of PDGFR-β in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-24)
Due to a lack of sufficient diagnostic tools to predict aggressive disease, there is a significant overtreatment of patients with prostate cancer. Platelet derived growth factors (PDGFs) and their receptors (PDGFRs) are key regulators of mesenchymal cells in the tumor microenvironment, and has been associated with unfavorable outcome in several other cancers. Herein, we aimed to investigate the ...
Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation,
growth and progression, and is widely used in routine clinicopathological investigation.
Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and
overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to
assess Ki-67 expression and related ...
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)
Objectives: <br>
Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize
with immune-checkpoint inhibitors. While the roles of CAFs in cancer development are well
described, their immune-regulatory properties remain incompletely understood. This study
investigates correlations between CAF and immune-markers in tumor stroma from nonsmall
cell lung cancer (NSCLC) ...
The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)
Programmed cell death protein 1 (PD-1) and its ligand Programmed death ligand
1 (PD-L1) have gained massive attention in cancer research due to recent availability
and their targeted antitumor effects. Their role in prostate cancer is still undetermined.
We constructed tissue microarrays from prostatectomy specimens from 535 prostate
cancer patients. Following validation of antibodies, ...
Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: Combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-29)
Background: The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human cancers; however no studies have yet investigated their influence on prognosis in non-small cell lung cancer (NSCLC). We aimed to explore their prognostic significance in NSCLC, in ...
Stromal Expression of MiR-21 Predicts Biochemical Failure in Prostate Cancer Patients with Gleason Score 6
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Bronchial airway gene expression in smokers with lung or head and neck cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Does chemotherapy improve Quality of Life in NSCLC PS 2?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-03)
Introduction
<br>Nearly 40% of patients with advanced NSCLC are in performance status (PS) 2. These patients have a shorter life expectancy than PS 0/1 patients and they are underrepresented in clinical trials. Data on how platinum-based combination chemotherapy affects Health Related Quality of Life (HRQOL) of patients with PS 2 are scarce and the treatment of this important group of patients is ...
Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ...
Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIFregulated
glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue
sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from206 patients with non-GIST STS were obtained
and tissue microarrays were constructed. ...