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Probability revision in general practice: the cases of occult blood in stool in patients with indigestion, and daily smoking in patients who cough
(Journal article; Tidsskriftartikkel; Peer reviewed, 1990)
Prior calculation of the sex- and age-distributed
positive predictive value (PPV) of a symptom
in relation to a disease forms the basis for probability
revision based on new information about signals
observed during the medical encounter: a symptom, a
sign, a piece of information based on the medical history, a laboratory test. Probability revision requires
estimates of sensitivity and specificity ...
A method of calculating diagnostic indexes for possible cancer symptoms in general practice
(Journal article; Tidsskriftartikkel; Peer reviewed, 1990)
Most medical encounters start with the presentation
of symptomns that lead to hypotheses about
the diagnosis. It might be useful to know the probability
of a disease when a symptom of it is presented in
a consulation with a general practitioner, i.e., the
positive predictive value (PPV) of a particular symptom
in relation to a disease. A diagnostic index of this
kind would need to be based ...
Evening melatonin in January after changes in hours of habitual exercise during fall among youths living in the subarctic.
(Journal article; Tidsskriftartikkel; Peer reviewed, 1994)
Secretion of the hormone melatonin shows a circadian rhythm and is inhibited by
light. Light therapy with phase shifting of the melatonin rhythm has been used
as treatment of sleeping problems and seasonal affective disorders (SAD). Exercise
has also been shown to suppress the melatonin secretion. In order to investigate
the effect of increased level of habitual physical activity upon ...
More diagnostic indexes from general practice for some important forms of cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 1990)
A method of calculating positive predictive
values (PPVs) and likelihood ralios (LRs) on the basis
of Bayesian probabilities has been described previously.
In the present article the method is applied to a sore
which does not heal in relation to skin cancer, a lump
in the breast in relation to female breast cancer, genital
bleeding in relation to internal genital cancer in
fernales and ...
Salivary glands in Svalbard reindeer (Rangifer tarandus platyrhynchus) and in Norwegian reindeer (Rangifer tarandus tarandus).
(Journal article; Peer reviewed; Tidsskriftartikkel, 1999)
The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide
(Journal article; Tidsskriftartikkel; Peer reviewed, 1994)
The present study was performed to examine whether residues 36–62 of TNFα contain the chemotactic domain of TNFα, and whether the p55 and p75 TNF receptors are involved in TNFα induced chemotaxis. The chemotactic effect of TNFα on PMN was inhibited by the mAbs Hrt-7b and Utr-1, against the p55 and p75 TNF receptors, respectively. Both receptors may therefore be required for mediating the chemotactic ...
Endothelin-1 Stimulates Monocytes in vitro to Release Chemotactic Activity Identified as Interleukin-8 and Monocyte Chemotactic Protein-1
(Journal article; Tidsskriftartikkel; Peer reviewed, 1994)
In the present study we examined whether endothelin-1 stimulation of human monocytes causes release of chemotactic factors. It was found that monocytes released neutrophil- and monocyte-chemotactic activity in a dose- and time-dependent manner in response to ET-1. ET-1 did not show any chemotactic activity by itself. NCA was detected in monocyte supernatants in response to ET-1 (0.01–100 nM) after ...
Endothelin-1 stimulates human monocytes in vitro to release TNF-α, IL-1β and IL-6
(Journal article; Tidsskriftartikkel; Peer reviewed, 1993-09-09)
INCREASED plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages.
ET-1 increased secretion of TNF-α, IL-1β and
IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ...
Betydelsen av teori- och metodutvecklingen inom historieskrivningen för undervisningen i ämnet teknikhistoria
(Journal article; Tidsskriftartikkel; Peer reviewed, 1990)