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Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor
(Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2020-01-10)
<i>Background</i> - BK Polyomavirus (BKPyV) causes premature graft failure in 1 to 15% of kidney transplant (KT) recipients. High-level BKPyV-viruria and BKPyV-DNAemia precede polyomavirus-associated nephropathy (PyVAN), and guide clinical management decisions. In most cases, BKPyV appears to come from the donor kidney, but data from biopsy-proven PyVAN cases are lacking. Here, we report the early ...
Clinical manifestations and novel pathogenic variants in SOX10 in eight Danish probands with Waardenburg syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2021-06-22)
The SRY-related HMG box gene 10 (SOX10), located on 22q13.1, encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate and differentiation. SOX10 is one of the six causal genes for Waardenburg syndrome, which is a dominantly inherited auditory-pigmentary disorder characterized by sensorineural hearing impairment ...
Functional screening of a human saliva metagenomic DNA reveal novel resistance genes against sodium hypochlorite and chlorhexidine
(Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2021-12-09)
Objective - Many sections of the health care system are facing a major challenge making infectious disease problematic to treat; antimicrobial resistance (AMR). Identification and surveillance of the resistome have been highlighted as one of the strategies to overcome the problem. This study aimed to screen for AMR genes in an oral microbiota, a complex microbial system continuously exposed to ...
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2020-01-27)
<p><i>Background - </i>The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated.
<p><i>Aim - </i>To study the combined effect of MI and ...
The relationship between smokeless tobacco (snus) and anxiety and depression among adults and elderly people. A comparison to smoking in the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2022-05-23)
<p><b>Aims</b>
To (i) define the characteristics of snus users compared with non-users and smokers and (ii) define the relationship between snus use and self-reported anxiety and depression and compare it with the relation between smoking and anxiety and depression.
<p><b>Design, setting and participants</b>
A cross-sectional study based on data from the Norwegian population-based survey, ...
Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer — A Multi-Institutional Study
(Master thesis; Mastergradsoppgave; Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
<p><i>Background:</i> MicroRNAs (miRs) have critical regulatory roles in cell functions, and are involved in prostate cancer tumorigenesis. miR-20a-5p is a member of the oncogenic miR-17-92 cluster. Overexpressed miR-20a-5p has been shown to increase both cell proliferation and cell migration in cancers. The aim of our cohort study was to evaluate the prognostic role of miR-20a-5p in prostate cancer. ...