Now showing items 1-10 of 26
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better
(Journal article; Preprint; Tidsskriftartikkel; Peer reviewed; Manuskript, 2015-06-25)
To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ...
Asialoglycoprotein Receptor (ASGP-R) is Liver Parenchymal Cells is Involved in Elimination of Recombinant Human TFPI
(Preprint; Manuskript; Peer reviewed, 2010)
We here report on a study carried out to determine the early clearance kinetics, and organ, cell(s) and receptor(s) responsible for the clearance of full length TFPI purified from BHK cells (TFPI<sup>BHK</sup>). Following intravenous administration, <sup>125</sup>I-TFPI<sup>BHK</sup> was cleared with a biphasic elimination curve, and with a significantly slower t<sub>1/2</sub>α compared to recombinant ...
Effect of Unfractionated Heparin on TFPI Elimination
(Preprint; Manuskript; Peer reviewed, 2010)
Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ...
Samnett – en arena for tverrprofesjonelt engasjement : et virtuelt fagnett for helsefagstudenter ved Universitetet i Tromsø
(Preprint; Manuskript, 2010-12)
Denne rapporten er en del av CAB-prosjektet (Collaboration Across professional Boundaris) som er et fellesprosjekt mellom åtte høgskoler og universitet. Rapporten er utarbeidet ved Universitetet i Tromsø (UiT). Problemstillingen er i hvilken grad e-læring kan støtte opp om UiTs helsefagstudenters samarbeidslæring med tanke på å utvikle tverrprofesjonell samarbeidskompetanse. Hensikten med prosjektet ...
Acculturation : early political and social science conceptions
(Preprint; Manuskript, 2003-10)
Improved Cardiac Metabolism Following in Vivo Treatment of Type 2 Diabetic Mice with Fenofibrate Depends on Reduction of Plasma Lipids, as Well as Glucose
(Preprint; Manuskript, 2009-01-16)
The plasma supply of energy substrates plays a key role in determining the cardiac metabolic phenotype. In diabetes, a high plasma supply of fatty acids (FA) leads to a predominant oxidation of FA for energy production, while glucose oxidation is markedly suppressed. The db/db mouse is a well accepted model of type 2 diabetes, showing hyperglycemia, hyperlipidemia, and hyperinsulinemia. Hearts from ...
Testing alternative regression models to predict utilities: mapping the QLQ-C30 onto the EQ-5D-5L and the SF-6D
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2018-09-01)
<p><i>Purpose</i>: The purpose of the study was to compare alternative statistical techniques to find the best approach for converting QLQ-C30 scores onto EQ-5D-5L and SF-6D utilities, and to estimate the mapping algorithms that best predict these health state utilities.</p> <p><i>Methods</i>: 772 cancer patients described their health along the cancer-specific instrument (QLQ-C30) and two generic ...
Interprofessional student meetings in municipal health service - Mutual learning towards a community of practice in patient care
(Preprint; Manuskript, 2018-09-12)
Mutual engagement is fundamental in interprofessional collaboration. This paper investigated how mutual engagement evolves in interprofessional student meetings when medical, nursing, occupational therapy and physiotherapy students shape their own collaboration and learning in patient care. We conducted a qualitative study with an ethnographic design. The data material consists of 200 hours of ...
Behavioral responses to emotional challenges in female rats living in a seminatural environment: The role of estrogen receptors
(Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-11-06)
Estrogen receptors (ERs) are involved in sexual as well as non-sexual behaviors. In the present study we assessed the effects of stimuli inducing positive or negative affect on sociosexual, exploratory and fear-related behaviors of female rats housed in groups (4 females, 3 males) in a seminatural environment. Ovariectomized females were treated with oil, 17β‑estradiol benzoate (EB, 18 μg/kg), the ...
Action-associated modulation of visual event-related potentials evoked by abstract and ecological stimuli
(Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-09-19)
This study investigated the influence of action‐associated predictive processes on visual ERPs. In two experiments, we sought evidence for sensory attenuation (SA) indexed by ERP amplitude reductions for self‐induced stimuli when compared to passive viewing of the same images. We assessed if SA is (a) present for both ecological and abstract stimuli (pictures depicting hands or checkerboards), (b) ...