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Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D
(Master thesis; Mastergradsoppgave, 2015-10-29)
Introduction/background
In the circulation 25-hydroxyvitamin D (25(OH)D) is bound to vitamin D-binding protein (DBP) and albumin. Only a small fraction is in the unbound, free form. According to the ‘free-hormone-hypothesis’ only the free form is biologically active. Genetic differences in DBP may affect the binding to 25(OH)D and thereby the amount of free 25(OH)D.
Methods
In the present study ...
No lipid lowering effect of vitamin D supplements found on statin users.
(Master thesis; Mastergradsoppgave, 2015-08-26)
Background
Tromsø endocrine research group has performed multiple RCTs with vitamin D supplements/placebo and effects on different outcomes. Compiling data from four of these studies I tested an hypothesis established by Kane et al. in 2013, which suggests that vitamin D supplements have a significant lipid lowering effect in statin users. Retesting hypotheses in general is vital to the scientific ...