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Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
<i>Background</i>: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.<p>
<p><i>Objective</i>: To characterize breast cancer risk in relation to recent childbirth.<p>
<p>Design</i> : Pooled ...
Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the ...
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-25)
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the
risk of colorectal cancer (CRC) development. We examined the association between CRC risk and
genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway
genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants
in 154 genes ...
Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...
Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-04)
Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation ...
Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)
Background & Aims - There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. ...
Healthy lifestyle and the risk of pancreatic cancer in the EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-28)
Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) ...
Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)
Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 ...
Consumption of meat, fish, dairy products, and eggs and risk of ischemic heart disease: A prospective study of 7198 incident cases among 409 885 participants in the Pan-European EPIC Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)
<i>Background</i>
- There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition).<P><P>
<i>Methods</i>
- In this prospective study of 409 885 men and women in 9 European countries, diet ...
Association between soft drink consumption and mortality in 10 European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-03)
<i>Importance</i> - Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date.<p><p>
<i>Objective</i> - To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality.<p><p>
<i>Design, ...