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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-23)
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, ...
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-01)
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI,
WHRadjBMI), a measure of body shape. Body size and shape change as people grow older
and these changes differ substantially between men and women. To systematically screen
for age- and/or sex-specific effects of genetic variants ...