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Osteoprotegerin and breast cancer risk by hormone receptor subtype: A nested case-control study in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-08)
Background:<br>Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.<br>Methods:<br>A case-control ...
A comprehensive analysis of the androgen receptor gene and risk of breast cancer. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-20)
Introduction
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer ...
Social Inequalities and Mortality in Europe - Results from a Large Multi-National Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans.
A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and ...
Multiple miscarriages are associated with the risk of ovarian cancer: results from the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
While the risk of ovarian cancer clearly reduces with each full-term pregnancy, the effect of incomplete pregnancies is unclear. We investigated whether incomplete pregnancies (miscarriages and induced abortions) are associated with risk of epithelial ovarian cancer. This observational study was carried out in female participants of the European Prospective Investigation into Cancer and Nutrition ...
Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries : a prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-02-15)
Background: Several countries are discussing new legislation on the ban of smoking in public
places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate
the burden of disease associated with indoor and outdoor air pollution.
Methods: We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air
pollution in never smokers and ex-smokers ...
Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
Background<br>
Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br>
Methods<br>
We analysed data from 264,906 European adults from the ...
The premenopausal breast cancer collaboration: A pooling project of studies participating in the national cancer institute cohort consortium
(Journal article; Tidsskriftartikkel, 2017-09)
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual ...
Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-07-29)
Background: Gonadotropin releasing hormone (GNRH1) triggers the release of follicle
stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene
encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of
ovarian steroid hormones. We studied the association between breast cancer risk and
polymorphisms in genes that code for GNRH1 ...
Consumption of dairy products and colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of
total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for
individual dairy products with differing fat contents.
Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), ...
Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently.
We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.<p>
<p>Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer
(EPIC) Study, completed a dietary ...