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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-12)
<b>Background:</b> <br>
Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic
control in patients with diabetes. Previous genome-wide association studies (GWAS)
have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable
by their likely biological action as erythrocytic (also associated with erythrocyte traits)
or ...
Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979–2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-08)
The data presented in this article relate to the research article entitled “Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979–2012” (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, ...
Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
Objectives: <br> There is a shift in the smoking population
from daily smokers to light or occasional smokers. The
knowledge about possible adverse health effects of this
new smoking pattern is limited. We investigated smoking
habits with focus on occasional smoking in relation to
total mortality in a follow-up study of a Norwegian general
population. <br>
Setting: <br> A population study ...
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-21)
Objectives: <br> Elevated blood cholesterol is a modifiable
risk factor for cardiovascular disease. Cholesterol level
surveillance is necessary to study population disease
burden, consider priorities for prevention and intervention
and understand the effect of diet, lifestyle and treatment.
Previous studies show a cholesterol decline in recent
decades but lack data to follow individuals born ...
Resting heart rate trajectories and myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-25)
Background: <br>Resting heart rate (RHR) is an established risk factor for cardiovascular disease (CVD),
but long-term individual RHR trajectories and their effect on CVD morbidity and mortality have not
yet been described. <br>
Methods: <br>This large population-based longitudinal study included 14,208 men and women aged 20
years or older, not pregnant, and not using blood pressure medications, ...
Myocardial infarction and future risk of cancer in the general population—the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Background:<br>Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.<br>Methods:<br>In a European ...