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The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2005)
The transcription factor Pax6 is essential for the development of the eyes and the central nervous system of vertebrates and invertebrates. Pax6 contains two DNA-binding domains; an N-terminal paired domain and a centrally located homeodomain. We have previously shown that the vertebrate paired-less isoform of Pax6 (Pax6ΔPD), and several other homeodomain proteins, interact with the full-length ...