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Improved Cardiac Metabolism Following in Vivo Treatment of Type 2 Diabetic Mice with Fenofibrate Depends on Reduction of Plasma Lipids, as Well as Glucose
(Preprint; Manuskript, 2009-01-16)
The plasma supply of energy substrates plays a key role in determining the cardiac metabolic phenotype. In diabetes, a high plasma supply of fatty acids (FA) leads to a predominant oxidation of FA for energy production, while glucose oxidation is markedly suppressed. The db/db mouse is a well accepted model of type 2 diabetes, showing hyperglycemia, hyperlipidemia, and hyperinsulinemia. Hearts from ...