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Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
Background
Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and
health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and
mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This
may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism
(SNP) of the vitamin D receptor ...
The DBP Phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-18)
Background and Objective
In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect
lipid metabolism, inflammation and carcinogenesis. There are three common variants
of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/
1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two
single ...