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Endothelin-1 stimulates human monocytes in vitro to release TNF-α, IL-1β and IL-6
(Journal article; Tidsskriftartikkel; Peer reviewed, 1993-09-09)
INCREASED plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-α, IL-1β and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ...