Now showing items 131-140 of 461
Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development
(Doctoral thesis; Doktorgradsavhandling, 2015-04-17)
Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ...
Ecotoxicological assessment of Roundup-ready soybean agriculture investigated in a D. magna model
(Doctoral thesis; Doktorgradsavhandling, 2015-06-09)
Transgenic glyphosate tolerant soybeans are constituents of an industrial production system with specific agricultural practices and supplementary agrochemicals as interwoven additional elements. Thus the material produced should not be seen as an isolated product of a specific modified genotype but rather as a product of a tailored agriculture system. This globally dominant crop has been in open ...
Pulse oximetry in an adult population: Predictors of low oxygen saturation and associations with mortality; The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2015-03-19)
Pulsoksymetri er en enkel undersøkelsesmetode for å beregne metningen av oksygen (O2) i arterielt blod (SpO2). Lave verdier kan være indikasjon på hjerte- og/eller lungesykdom. Ingen befolkningsundersøkelser har tidligere sett på oksygenmetning i en voksen befolkning. Avhandlingen er basert på de to befolkningsundersøkelsene, Tromsø 5 (2001/2002) og Tromsø 6 (2007/2008). I disse ble det gjort ...
The hemodynamic aspects of pharmacological manipulation of cardiac contractility and vascular resistance in rewarming from hypothermia
(Doctoral thesis; Doktorgradsavhandling, 2018-12-07)
<p><i>Paper I</i> <br>To describe hemodynamic response and phosphorylation of cardiac troponin I during rewarming from deep, stable hypothermia with use of the calcium sensitizer and PDE3 inhibitor levosimendan, compared to animals given placebo. <p> <p><i>Paper II</i> <br>To describe hemodynamic response to lowered systemic vascular resistance by nitroprusside administration during rewarming ...
Cancer therapy-induced oral mucositis in head and neck cancer patients
(Doctoral thesis; Doktorgradsavhandling, 2015-06-17)
Background: Radiotherapy causes oral mucositis (OM) that is painful and disrupts eating, talking, social activities and general health. OM may even interrupt cancer therapy. Any intervention that can reduce OM will lead to improvement in treatment and quality of life for patients. It is essential to have a suitable tool to measure potentially effective and new treatments against OM. Objective: To ...
Arm function and constraint-induced movement in early post-stroke rehabilitation
(Doctoral thesis; Doktorgradsavhandling, 2015-09-10)
Constraint-induced movement therapy (CIMT) is a treatment for mild-to-moderate upper extremity motor dysfunction in post-stroke patients. However, as the ideal time to initiate post-stroke treatment remains uncertain, more information is needed regarding the effects of CIMT and arm use in the early stages of stroke recovery. This thesis aimed to: 1) examine the correlations between arm motor ...
Remuneration and organization in general practice: Three essays on doctors' preferences
(Doctoral thesis; Doktorgradsavhandling, 2015-10-16)
The need for recruiting and retaining general practitioners (GPs) is expected to increase substantially in the next years, both because of an ageing population and a reform suggesting to shift more resources to primary care. This will not only reinforce the current challenge of recruitment and retention in rural areas, but it may also make it more difficult to recruit and retain GPs in urban areas. ...
Novel chitosan-containing liposomes as mucoadhesive delivery system for vaginal administration
(Doctoral thesis; Doktorgradsavhandling, 2015-10-02)
Treatment of vaginal infections remains unsuccessful due to recurrent infections and limited patient compliance. Current therapies are unable to penetrate bacterial and fungal biofilms, allowing the survival of microorganisms, which often leads to new infections. Local administration of drug is able to provide a higher drug concentration at the vaginal site; enabling the administration of lower drug ...
Angiogenic markers as prognostic factors in non-small cell lung cancer (NSCLC)
(Doctoral thesis; Doktorgradsavhandling, 2014-01-31)
Antimicrobial resistance and bacterial diversity in Arctic environments
(Doctoral thesis; Doktorgradsavhandling, 2011-06-01)
Ampicillin er et antibiotikum som har vært brukt i flere tiår, og det er mange bakterier på sykehus og andre helseinstitusjoner som har utviklet resistens mot dette legemiddelet. Bakteriene blir resistente ved selv å utvikle eller ta opp resistensgener. Vi vet lite om bakteriene utenfor sykehusmiljøene har resistensgener mot ampicillin. Kunnskap om resistensgener i miljø hvor det er lite menneskelig ...