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Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-01)
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually ...
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
Background<br>
Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br>
Methods<br>
We analysed data from 264,906 European adults from the ...
Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-04)
Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and
progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer
are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited
385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs ...
Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-11)
Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included ...
Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-19)
Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-20)
Background: Much of the current literature on diet–colorectal cancer (CRC) associations focused on studies of single foods/
nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and
CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
<p>Methods: Among 477 312 participants, ...
Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Recently, some US cohorts have shown a moderate association between red and processed meat
consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study
was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death
in the European Prospective Investigation into Cancer and Nutrition ...
Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
<br>Methods: Over half a million ...