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Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant ...
Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting ...
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
Introduction: <br>
To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated.
<br>Materials and ...
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...
Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-30)
Background:
Prostate cancer (PC) stratification needs new prognostic tools to reduce overtreatment. Phosphatase of regenerating liver (PRL-3) is a phosphatase found at high levels in several cancer types, where its expression is associated with survival. A recent PC cell line study has shown it to be involved in PC growth and migration.
<br>Methods:
We used a monoclonal antibody to evaluate ...
Prognostic Impact of Fibroblast Growth Factor 2 in NSCLC : Co-Expression with VEGFR-3 and PDGF-B Predicts Poor Survival
(Tidsskriftartikkel; Peer reviewed; Journal article, 2009-05)
Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis.
Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact ...
Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
Recent data indicate that tumor-associated neutrophils (TANs) serve a dual role in tumor progression and regression. CD66b is a neutrophil marker and has been associated with patient outcome in various cancers. However, its clinical impact in non-small cell lung cancer (NSCLC) remains controversial. 536 NSCLC patients, of which 172 harbored lymph node metastases, were included in this study. Tissue ...
Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)
There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”,
microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied
in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells
and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy
patients ...
Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)
Androgens are considered important in normal prostate physiology and prostate cancer (PCa)
pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking.
This indicates additional mediators contributing to cancer development. We sought to determine the
prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue
microarrays ...
The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-07)
background: Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who will succumb to, and those who will eventually be cured from, their disease. ...