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Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-01)
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually ...
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
Background<br>
Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br>
Methods<br>
We analysed data from 264,906 European adults from the ...
A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-23)
Objective: Pattern analysis has emerged as a tool to depict the role of multiple
nutrients/foods in relation to health outcomes. The present study aimed at
extracting nutrient patterns with respect to breast cancer (BC) aetiology.<br>
Design: Nutrient patterns were derived with treelet transform (TT) and related to
BC risk. TT was applied to twenty-three log-transformed nutrient densities ...
Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-11)
Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included ...
Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-13)
Background: The etiology of small intestinal cancer (SIC)
is largely unknown, and there are very few epidemiological
studies published to date. No studies have investigated
abdominal adiposity in relation to SIC.
<p>Methods: We investigated overall obesity and abdominal
adiposity in relation to SIC in the European Prospective
Investigation into Cancer and Nutrition (EPIC), a large
prospective ...
Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Recently, some US cohorts have shown a moderate association between red and processed meat
consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study
was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death
in the European Prospective Investigation into Cancer and Nutrition ...
Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
(Journal article; Tidsskriftartikkel, 2017-06-21)
Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study ...
Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-07)
Insulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations ...