Now showing items 11-20 of 21
Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...
Hematocrit and risk of venous thromboembolism in a general population. The Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-10)
Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between ...
Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated ...
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)
Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth ...
Atrial Fibrillation and Cause-Speciﬁc Risks of Pulmonary Embolism and Ischemic Stroke
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
<p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
Myocardial infarction and future risk of cancer in the general population—the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...
Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
<i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ...