Now showing items 11-20 of 527
Epidemiology and Outcome of Ankylosing Spondylitis in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2012-05-29)
Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
(Doctoral thesis; Doktorgradsavhandling, 2010-12-03)
The work is part of a larger thematic research initiative, “Airway reactions to biological particles derived from seafood”, and was initiated in 2005 after a study conducted in the Norwegian fish industry revealed increased airway symptoms in fish industry workers. The thesis investigates the ability fish and king crab trypsins have to affect airway epithelial cells and the initiation of intracellular ...
The consumption of lean and fatty fish, different dietary patterns, and the risk of cancers of various sites
(Doctoral thesis; Doktorgradsavhandling, 2008-05-24)
The present work includes women from three cohorts: the Norwegian Women and Cancer (NOWAC) study, the European Prospective Investigation into Cancer and Nutrition (EPIC) study, and a sub-cohort from the NOWAC study termed the Norwegian EPIC cohort (NEPIC). <br>Despite large differences in nutritional values in lean and fatty fish most studies on fish consumption and cancer do not diverse between ...
Pattern recognition receptors in liver sinusoidal endothelial cells : Roles in the innate immune system and scavenger functions
(Doctoral thesis; Doktorgradsavhandling, 2011-05-05)
Effective removal of unwanted self and non-self molecules from blood is essential to keep the organism healthy. Liver sinusoidal endothelial cells (LSECs) have been shown to effectively clear such macromolecules via receptor-mediated endocytosis. The cells express several high affinity endocytosis receptors, including the mannose receptor (MR), and several scavenger receptors (SRs), which are known ...
Kinetic and docking studies of inhibitors targeting the catalytic zinc in MA clan enzymes
(Doctoral thesis; Doktorgradsavhandling, 2011-12-07)
Kinetikk og docking studier av inhibitorer som binder seg til zink i MA klan enzymer Enzymer er biokatalyster som trengs for at kroppen vår skal fungere og i bunn og grunn er de nødvendige for at liv skal eksistere. Disse får reaksjoner til å skje i en tidsramme som er gunstig for kroppen vår. Naturlig nok må arbeidet til enzymene reguleres av kroppen vår, og det har derfor blitt utviklet mange ...
The development and use of a new tool for estimating individual sun induced vitamin D in epidemiological surveys
(Doctoral thesis; Doktorgradsavhandling, 2010-11-19)
A five-year prospective follow-up of longstanding eating disorders : influence from personality disorders and child sexual abuse
(Doctoral thesis; Doktorgradsavhandling, 2010-05-05)
Follow-up studies have shown that 20-30% of patients with eating disorders develop longstanding symptoms seriously impairing their daily life. There are very few studies on the course of these patients. <br>This dissertation consists of three papers on patients admitted to a specialized inpatient treatment program at the Modum Bad psychiatric hospital. The participants were assessed upon admission, ...
Hormone therapy use, sex hormone concentrations and gene expression : The Norwegian Women and Cancer study (NOWAC)
(Doctoral thesis; Doktorgradsavhandling, 2010-08-27)
I følge salgsstatistikken økte forbruket av hormontilskudd kraftig i Norge på 1990-tallet, men avtok fra 2002. Både hormontilskudd og kroppens egenproduserte kjønnshormoner er relatert til kreft hos kvinner, bl.a. brystkreft. Kreft karakteriseres ved ukontrollert celledeling som utvikles gradvis gjennom endringer i genmaterialet. Teknologisk utvikling gjør det mulig å utforske sammenhenger mellom ...
The sick-listed : an under-recognised resource in handling sickness absence
(Doctoral thesis; Doktorgradsavhandling, 2006-04-29)
In July 1993, several measures to stimulate return to work, like Active Sick Listing, formal decisions on sick leave beyond 12 weeks and commitments for employers to consider potential job adjustment were incorporated. The role of sickness as main cause to be entitled sickness benefits was simultaneously emphasised. However, despite av increasing focus on improving the necessary medical certificates ...
Specificity and HLA-restriction of CD4 T Cells Associated with Neonatal Alloimmune Thrombocytopenia
(Doctoral thesis; Doktorgradsavhandling, 2011-03-31)
The immune system is efficiently protecting us against infections by recognizing foreign structures; however it can occasionally cause complications during pregnancy by eliciting immune responses against foetal blood cells. Blood platelets have surface proteins that exist in different variants in the population. Those that are known to be a target for alloimmune responses are referred to as human ...