Now showing items 2451-2460 of 2697
A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
Micro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in NSCLC tissue. Tissue from 553 ...
Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes ...
Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are unclear. We identify the ROSgenerating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice. Myocardial Nox4 levels ...
Complementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trials
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-26)
<i>Background</i>: Due to limitations of conventional medicine for atopic eczema (AE), complementary and alternative medicine (CAM) is widely used as an alternative, maintaining, or simultaneous treatment for AE. We aimed to evaluate the beneficial and harmful effects of CAM for children with AE under 14 years old.<p> <p><i>Methods</i>: We searched for randomized trials on CAM in 12 Chinese and ...
Achieving Thoracic Oncology data collection in Europe: a precursor study in 35 Countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-20)
<i>Background</i>: A minority of European countries have participated in international comparisons with high level data on lung cancer. However, the nature and extent of data collection across the continent is simply unknown, and without accurate data collection it is not possible to compare practice and set benchmarks to which lung cancer services can aspire.<p> <p><i>Methods</i>: Using an ...
Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-16)
Thrombospondin-1-deficient (TSP-1−/−) mice are used as an animal model of Sjögren’s Syndrome because they exhibit many of the symptoms associated with the autoimmune type of dry eye found in primary Sjögren’s Syndrome. This type of dry eye is linked to the inflammation of the lacrimal gland, conjunctiva, and cornea, and is thought to involve dysfunction of the complex neuronal reflex arc that ...
Complications, reoperations, readmissions, and length of hospital stay in 34 639 surgical cases of lumbar disc herniation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-01)
<i>Aims</i>: The aims of this study were to determine the rates of surgical complications, reoperations, and readmissions following herniated lumbar disc surgery, and to investigate the impact of sociodemographic factors and comorbidity on the rate of such unfavourable events.<p> <p><i>Patients and Methods</i>: This was a longitudinal observation study. Data from herniated lumbar disc ...
Commentary: Transcranial stimulation of the frontal lobes increases propensity of mind-wandering without changing meta-awareness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-05)
A Commentary on <p> <p>Transcranial stimulation of the frontal lobes increases propensity of mind-wandering without changing meta-awareness<p> <p>by Axelrod, V., Zhu, X., & Qui, J. (2018). <i>Scientific Reports</i>, 8:15975. doi: 10.1038/s41598-018-34098-z
Linking interprofessional work to outcomes for employees: A meta‐analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-14)
The aim of this meta‐analysis of studies of workers in the health and social care sector was to examine the relationship between interprofessional work and employee outcomes of job stress, autonomy, burnout, engagement, job satisfaction, turnover intention, and perceived service quality, and to examine the influence of different moderators on those relationships. A systematic literature search of ...
Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-10)
<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer’s disease.<p> <p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective ...