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Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)
In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring ...
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the cell is currently unclear. We here determine four high-resolution cryo-EM structures of different human ...
Workplace Cold and Perceived Work Ability: Paradoxically Greater Disadvantage for More vs. Less-Educated Poultry Industry Workers in Thailand
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
The association between worksite temperature and perceived work ability (WA) in various
educational classes remains unknown. Therefore, we interviewed 286 poultry industry
workers in Thailand about their WA and linked their responses to worksite temperature.
WA was based on the self-assessment of current work ability compared with their lifetime
best ability (scores 0–10). Education was classified ...
The proposed Drug Resistance Index (DRI) is not a good measure of antibiotic effectiveness in relation to drug resistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-21)
Summary box<p>
<ul>
<li>The Drug Resistance Index (DRI) is proposed as measure of antibiotic effectiveness in a given country, by combining, in a single metric the use of various antibiotic groups and the resistance proportions of several pathogens.</li>
<li>The DRI is a complicated measure that gives results that cannot be understood by common knowledge and logic.</li>
<li>The DRI conveys ...
Organizing work in local service implementation: an ethnographic study of nurses’ contributions and competencies in implementing a municipal acute ward
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-19)
<i>Background</i> - The increased prevalence of chronic diseases and an ageing population challenge healthcare delivery, particularly hospital-based care. To address this issue, health policy aims to decentralize healthcare by transferring responsibility and introducing new services in primary healthcare. In-depth knowledge of associated implementation processes is crucial for health care managers, ...
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-07)
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, ...
Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-03)
Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on plasmids. It was recently discovered that transposition from fully heterologous DNA also occurs in the course of natural transformation. Here, we characterize the molecular details and constraints of this process using the replicative transposon ...
Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently.
We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.<p>
<p>Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer
(EPIC) Study, completed a dietary ...
Factors associated with exclusive breastfeeding at hospital discharge: a study using data from the Georgian Birth Registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-13)
<p><i>Background - </i>The World Health Organization recommends exclusive breastfeeding for six months, defined as no other solids or liquids besides breast milk and essential vitamins or medicines. Data about exclusive breastfeeding are limited in Georgia, and the information that exist are provided by national surveys, that present inconsistent numbers. Georgia has recently established a national ...
Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
Introduction: Alcohol consumption may promote aromatization of androgens to estrogens, which may partly
explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is
associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women
remains unclear.<p>
<p>Methods: Alcohol consumption was collected by self-report ...