Now showing items 2561-2570 of 2814
Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-10)
<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer’s disease.<p> <p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective ...
Psychometric Properties of the Norwegian Short Version of the Team Climate Inventory (TCI)
(Journal article; Tidsskriftartikkel, 2016)
<p><i>Objective: </i>To examine the psychometric properties of the short version of the Team Climate Inventory (TCI) in a Norwegian sample. <p><i>Method: </i>A multilevel confirmatory factor analysis (MCFA) was conducted using Mplus. The sample (<i>N</i> = 1380) comprised employees working in the private- (<i>n</i> = 657) and in the public sector (<i>n</i> = 723) in Norway. A multi-group comparison ...
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
<p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...
Hvordan møte utfordringer for fastlegetjenesten i distriktene?
(Journal article; Tidsskriftartikkel, 2018)
En god fastlegetjeneste er viktig, ikke minst der det er lang avstand til sykehus. I Nord-Norge er avstandene store, og gjennomsnittlig reisetid fra de 87 kommunesentra i Nord-Norge til nærmeste sykehus er 2 timer og 6 minutter. I denne artikkelen beskriver vi fastlegetjenesten i Nord-Norge samtidig som vi fokuserer på sentrale utfordringer som gjelder rekruttering av fastleger, det å få fastleger ...
Reorganisation of healthcare services for children and families: Improving collaboration, service quality, and worker well-being
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)
This study is an evaluation of a reorganization of different services for children and their families in a Norwegian municipality. The main aim of the reorganization was to improve interprofessional collaboration through integrating different social services for children and their parents. The evaluation was guided by the Job Demands-Resources Model with a focus on social- and health care workers' ...
Screening for Alzheimer’s Disease: Cognitive Impairment in Self-Referred and Memory Clinic-Referred Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-07)
<p>Background</i>: Cognitive assessment is essential in tracking disease progression in AD. Presently, cohorts including preclinical at-risk participants are recruited by different means, which may bias cognitive and clinical features. We compared recruitment strategies to levels of cognitive functioning.<p> <p><i>Objective</i>: We investigate recruitment source biases in self-referred and ...
Impact of incline, sex and level of performance on kinematics during a distance race in classical cross-country skiing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-01)
Here, female and male elite cross-country (XC) skiers were compared on varying terrain during an official 10-km (women) and 15-km (men) Norwegian championship race. On the basis of race performance, 82 skiers were classified as fast (FS) (20 women, 20 men) or slower (SS) (21, 21) skiers. All were video recorded on flat (0°), intermediate (3.5°), uphill (7.1°) and steep uphill (11°) terrain during ...
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-08)
<i>Background/Objective</i>: In recent years, several slightly younger cohorts have been established in order to study the preclinical and prodromal phases of dementia. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) wordlist memory test (WLT) is widely used in dementia research. However, culturally adapted and demographically adjusted test norms for younger ages are ...
Styringsutfordringer i ny søknadsbasert turnusordning
(Journal article; Tidsskriftartikkel, 2017)
Geografisk fordeling av leger er ett av målene med turnusordningen. Formålet med denne artikkelen er å peke på noen styringsutfordringer i den nye søknadsbaserte turnusordningen sett i lys av dette målet. De handler blant annet om selektiv oppmerksomhet fra helsemyndighetens side og mangler i samstyringen mellom helseforetak og kommuner.
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-19)
There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully elucidated. This study examined the effects of C5 in normal hemostasis and in <i>Escherichia coli</i>‐induced coagulation and tissue factor (TF) up‐regulation. Fresh whole blood ...