Søk
Viser treff 2591-2600 av 5961
Inside the clockwork of the ECHO factorial trial: A conceptual model with proposed mediators for prevention of emotional problems in children
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-21)
Having interventions that are not only evidence-based and effective but also cost-effective and efficient is important for the prevention and treatment of child and adolescent emotional problems. A randomized clinical trial (RCT) tests the totalinterventions effect but does not address specific components of the intervention.
In this article the hypothesis and a conceptual model of the ECHO study ...
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-11)
Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10−8). In addition to loci implicated in lymphocyte function and development shared with other ...
Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
Anti-angiogenic therapies were approved for different cancers. However,
significant primary and secondary resistance hampers efficacy in several tumor types
including breast cancer. Thus, we need to develop clinically applicable strategies to
enhance efficacy of anti-angiogenic drugs.
We report that anti-angiogenic therapies can induce upregulation of
cyclooxygenase-2 (Cox-2) and of its product ...
Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-15)
<i>Background</i>
- Antibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.<p><p>
<i>Aim</i>
- Our objective was to compare the country-specific species distribution of the four Gram-negative species <i>Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa</i> and <i>Acinetobacter</i> species and the proportions of selected acquired ...
Winter is coming: Wintertime mindset and wellbeing in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-30)
Previous research of the effect of winter on wellbeing has yielded contradictory findings. While there is evidence that the lack of sunlight in wintertime can lead to seasonal depression and negative emotions, many individuals are able to thrive during the winter. What might determine whether the darkness of winter leads to poor psychological outcomes? To investigate whether or not mindset contributes ...
Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-14)
Aim: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study.<p>
<p>Method: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as the gold standard, we calculated correctness (defined as positive predictive value, PPV) and ...
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre‐diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell ...
Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)
<i>Background:</i> Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer’s disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic.<p>
<p><i>Objective:</i> To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive ...
Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...
Specific interactions between the alkaline protease of P. aeruginosa and its natural peptide inhibitor: ab initio molecular simulations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
Alkaline protease aeruginolysin (APR) is an important virulence factor in the evasion of the immune system by Pseudomonas
aeruginosa (P. aeruginosa). The P. aeruginosa genome also encodes the highly potent and specifc APR peptide inhibitor
(APRin). However, the structural reason for the signifcant inhibition has not been revealed. Using ab initio molecular simulations, we here investigated the ...