Now showing items 2801-2810 of 2976
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-10)
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10<s ...
Leisure time and occupational physical activity, resting heart rate, and mortality in the Arctic region of Norway: The Finnmark Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-20)
<p><i>Aims - </i>This study examined the association of leisure time physical activity, occupational physical activity, and resting heart rate with all-cause and cardiovascular disease mortality in Sami and non-Sami populations. <p><i>Study design - </i>This was a longitudinal, observational population-based study. <p><i>Methods - </i>The Finnmark 3 study cohort was examined in 1987–1988 and ...
Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
<i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ...
Rural general practice patients’ coping with hazards and harm: an interview study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-18)
<i>Objective</i>: The aim of this study is to identify and analyse rural general practice patients’ experiences of hazards and harm that comprise adverse events, and their strategies for coping with them.<p> <p><i>Design</i>: Interview study using systematic text condensation and coping strategy theory in an abductive analysis process.<p> <p><i>Setting</i>: Nine rural general practice clinics ...
Mild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Control
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
Nalmefene is approved for as-needed pharmacological treatment in alcohol use disorder (AUD) by the European Medicines Agency. While the cellular effects of nalmefene have been thoroughly investigated, data are very limited on how this agent influences neural signals associated with inhibitory control and the visual analysis of environmental cues. This double-blind crossover study assessed the ...
Lekens plass i barnefysioterapi
(Journal article; Tidsskriftartikkel, 2018)
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-08)
<p><i>Background - </i>How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected ...
Increasing propensity to mind‐wander by transcranial direct current stimulation? A registered report
(Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2019-01-24)
Transcranial direct current stimulation (tDCS) has been proposed to be able to modulate different cognitive functions. However, recent meta‐analyses conclude that its efficacy is still in question. Recently, an increase in subjects’ propensity to mind‐wander has been reported as a consequence of anodal stimulation of the left dorsolateral prefrontal cortex (Axelrod et al., Proceedings of the National ...
Clinical Presentation of Gastroesophageal Reflux Disease: A Prospective Study on Symptom Diversity and Modification of Questionnaire Application
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-12)
<p><i>Introduction - </i>Symptoms occurring in gastroesophageal reflux disease (GERD) such as heartburn, regurgitation, thoracic pain, epigastric pain, respiratory symptoms, and others can show a broad overlap with symptoms from other foregut disorders. The goal of this study is the accurate assessment of symptom presentation in GERD. <p><i>Methods - </i>Patients with foregut symptoms were ...
Changes in conventional cardiovascular risk factors and the estimated 10-year risk of acute myocardial infarction or cerebral stroke in Sami and non-Sami populations in two population-based cross-sectional surveys: The SAMINOR Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)
<p><i>Objective - </i>To describe changes in cardiovascular risk factors and in the estimated 10-year risk of acute myocardial infarction (AMI) or cerebral stroke (CS) between SAMINOR 1 (2003–2004) and SAMINOR 2 (2012–2014), and explore if these changes differed between Sami and non-Sami. <p><i>Design - </i>Two cross-sectional surveys. <p><i>Setting - </i>Inhabitants of rural Northern Norway. < ...