Now showing items 21-30 of 66
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total ...
Physical activity and risk of venous thromboembolism. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and ...
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). <p>Methods: The health metric score was derived from ideal ...
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-22)
BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND ...
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-01)
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants ...
Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...
Health in overweight children: 2-year follow-up of Finnmark Activity School-a randomised trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-20)