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Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-21)
Objectives: <br> Elevated blood cholesterol is a modifiable
risk factor for cardiovascular disease. Cholesterol level
surveillance is necessary to study population disease
burden, consider priorities for prevention and intervention
and understand the effect of diet, lifestyle and treatment.
Previous studies show a cholesterol decline in recent
decades but lack data to follow individuals born ...
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)
Red cell distribution width (RDW), a measure of the variability in size
of the circulating erythrocytes, is associated with cardiovascular morbidity
and mortality. We aimed to investigate whether RDW was associated
with incident stroke and case fatality in subjects recruited
from the general population. Baseline characteristics were obtained
from 25,992 subjects participating in the fourth ...
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-23)
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, ...
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and
venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using
time-fixed analyses without and with correction for regression dilution and time-varying
analyses.<p>
<p><i>Methods:</i> ...
Quantification of the smoking-associated cancer risk with rate advancement periods: Meta-analysis of individual participant data from cohorts of the CHANCES consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)
Background:<br>
Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking ...
Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-07)
Background: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen
receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an
established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1
and premenopausal mammographic density phenotypes is unknown.
Methods: ...
Genetic Polymorphism CYP17 rs2486758 and Metabolic Risk Factors Predict Daily Salivary 17 beta-Estradiol Concentration in Healthy Premenopausal Norwegian Women. The EBBA-I Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-14)
Context: The relationship between low-penetrance genes, metabolic risk factors, and levels of endogenous 17β-estradiol and progesterone, which play a role in breast cancer risk, remains unclear.
<br>Objective: The aim of this study was to determine whether common polymorphisms in CYP17, in combination with metabolic risk factors (individually or clustered), alter salivary concentrations of free ...
Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
<i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the
strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate
the association between ischemic stroke and VTE in a prospective population-based cohort.<p>
<p><i>Methods and Results</i> - Participants (n=30 ...
Secular trends and correlates of physical activity: The Tromsø Study 1979-2008
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-03)
<b>Background: </b>The aim was to describe secular trends in leisure time physical activity (LTPA) and work related
physical activity (WPA) from 1979 to 2008. Additionally, we explored potential cross-sectional and longitudinal
correlates of LTPA and WPA.<br>
<b>Methods:</b> Data are collected from 34,898 individuals (49.7% men) aged >20 years who participated in at least one
Tromsø Study survey ...
Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ...