Now showing items 31-40 of 69
Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-15)
DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, ...
A processual model for functional analyses of carcinogenesis in the prospective cohort design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10)
Traditionally, the prospective design has been chosen for risk factor analyses of lifestyle and cancer using mainly estimation by survival analysis methods. With new technologies, epidemiologists can expand their prospective studies to include functional genomics given either as transcriptomics, mRNA and microRNA, or epigenetics in blood or other biological materials. The novel functional analyses ...
Ghiasvand et al. Respond to "Indoor Tanning-A Melanoma Accelerator?"
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-01)
Cancer incidence in Arkhangelskaja Oblast in northwestern Russia. The Arkhangelsk Cancer Registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2005-07-19)
Background: Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Europe. The oncological hospital in Arkhangelsk, in co-operation with Universitetet i Tromsø (Norway), has established a population based cancer registry for Arkhangelskaja Oblast ...
Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-30)
Background: Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. <p>Methods: The analysis was performed within the European Investigation into Cancer and Nutrition ...
Sex hormones and gene expression signatures in peripheral blood from postmenopausal women - the NOWAC postgenome study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Consumption of lean fish reduces the risk of type 2 diabetes mellitus: A prospective population based cohort study of Norwegian women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Epithelial ovarian cancer subtypes attributable to smoking in the Norwegian Women and Cancer Study, 2012
(Journal article; Peer reviewed; Tidsskriftartikkel, 2016-01-14)
Among European women, ovarian cancer is the fifth most common cancer. Smoking is an established risk factor for mucinous tumors. We estimated the impact of smoking in Norwegian women using population attributable fractions (PAFs) of epithelial ovarian cancer (EOC), by invasiveness and by histological subtypes in the Norwegian Women and Cancer Study with an average of 13.2 years of follow-up. ...
A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-05)
<b>Background: </b>The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of genes, based on measurements from many case-control pairs. We propose a new statistical method that does not assume any parametric shape for the gene trajectories. <br><b>Methods:</b> ...