Now showing items 31-40 of 164
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in longstanding eating disorders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-12-16)
Few consistent predictive factors for eating disorder have been identified across studies. In the current five year prospective study, the objective was to examine whether (1) personality disorder and child sexual abuse predict the course of severity of eating disorder symptoms after inpatient treatment and (2) how the predictors interact. A total of 74 patients with long standing eating disorder ...
Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption : an individual-level prescription database study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-12-05)
Background: A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. Our objective was to explore how differences in prevalences of use, dosing characteristics, choice of statin and continuity of therapy in individual patients adds new information ...
Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-05-02)
Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene. The intron (Nae.S516) has a complex organization of two ribozyme domains (NaGIR1 and NaGIR2) and a homing endonuclease gene (NaHEG). NaGIR2 is responsible for intron excision, exon ligation, and full-length intron RNA circularization, ...
Delayed leukocytosis after hard strength and endurance exercise. Aspects of regulatory mechanisms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2003-12-11)
Background: During infections, polymorphonuclear neutrophilic granulocytes (PMN) are mobilized from their bone marrow stores, travel with blood to the affected tissue, and kill invading microbes there. The signal(s) from the inflammatory site to the marrow are unknown, even though a number of humoral factors that can mobilize PMN, are well known. We have employed a standardized, non-infectious ...
Extravascular lung water assessed by transpulmonary single thermodilution and postmortem gravimetry in sheep
(Journal article; Tidsskriftartikkel; Peer reviewed, 2004-10-19)
Introduction: Acute lung injury is associated with accumulation of extravascular lung water (EVLW). The aim of the present study was to compare two methods for quantification of EVLW: transpulmonary single thermodilution (EVLWST) and postmortem gravimetric (EVLWG). Methods: Eighteen instrumented and awake sheep were randomly assigned to one of three groups. All groups received Ringer's ...
Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-03)
Background In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. ...
Measuring extravascular lung water. Animals and humans are not the same
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-07-24)
The evolution of extravascular lung water (EVLW) monitoring is an important step forward in the hemodynamic assessment of critically ill patients.
Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2005-03-04)
Introduction: Studies in vitro reveal that endothelin-1 (ET-1) activates the α isoform of protein kinase C (PKC-α) in cultures of endothelial cells, thereby deranging cellular integrity. Sepsis and endotoxemia are associated with increased plasma concentrations of ET-1 that induce acute lung injury (ALI). We recently reported that non-selective ET-1 receptor blockade attenuates ALI in sheep by ...
Scavenger properties of cultivated pig liver endothelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2004-08-12)
Background: The liver sinusoidal endothelial cells (LSEC) and Kupffer cells constitute the most powerful scavenger system in the body. Various waste macromolecules, continuously released from tissues in large quantities as a consequence of normal catabolic processes are cleared by the LSEC. In spite of the fact that pig livers are used in a wide range of experimental settings, the scavenger ...
Liver sinusoidal endothelial cells represents an important blood clearance system in pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2003-01-03)
Background: Numerous studies in rats and a few other mammalian species, including man, have shown that the sinusoidal cells constitute an important part of liver function. In the pig, however, which is frequently used in studies on liver transplantation and liver failure models, our knowledge about the function of hepatic sinusoidal cells is scarce. We have explored the scavenger function of pig ...