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Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
Background: The American Heart Association has proposed an impact goal for the year 2020 to improve
cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed
cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact
fraction (GIF).
<p>Methods: The health metric score was derived from ideal ...
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-01)
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI,
WHRadjBMI), a measure of body shape. Body size and shape change as people grow older
and these changes differ substantially between men and women. To systematically screen
for age- and/or sex-specific effects of genetic variants ...
Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
Background
Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and
health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and
mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This
may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism
(SNP) of the vitamin D receptor ...
N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ...
Association between diastolic dysfunction and future atrial fibrillation in the Tromsø Study from 1994 to 2010
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-13)
Objective. To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study.
Methods. We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. ...
Comparative effectiveness of antihypertensive medication of primary prevention of cardiovascular disease : systematic review and multiple treatments meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
We conducted a systematic review of evidence from randomized controlled trials to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducing the incidence of cardiovascular disease outcomes for healthy people at risk of cardiovascular disease?
We searched MEDLINE, EMBASE, AMED (up to February 2011) and CENTRAL (up to May 2009), ...
Incidence of and risk factors for type-2 diabetes in a general population: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in ...
Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine ...