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Cystatin C and cardiovascular disease: a Mendelian randomization study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)
BACKGROUND<br> Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.<br> OBJECTIVES<br>The aim of this study was to use Mendelian randomization ...
Tracking of overweight and obesity from early childhood to adolescence in a population-based cohort – the Tromsø Study, Fit Futures
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
BACKGROUND
Obesity is a serious childhood health problem today. Studies have shown that overweight and obesity tend to be stable (track) from birth, through childhood and adolescence, to adulthood. However, existing studies are heterogeneous; there is still no consensus on the strength of the association between high birth weight or high body mass index (BMI) early in life and overweight and ...
Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)
Background: <br>
Recurrent cardiovascular events after
myocardial infarction (MI) are frequent,
and gender
differences in blood pressure treatment have been
reported. Despite increased focus on secondary
prevention, recent reports indicate that treatment targets
are not achieved. There is a need for gender-specific
analyses of post-MI blood pressure treatment target
achievement and ...
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
Background: <br> Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health
consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI)
and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to
compare trends with those of adults.
<br>Methods: <br> ...
Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p>
<p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)
Introduction - Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary Stent Trial (NORSTENT). <p>
<p>Materials and methods - NORSTENT was a randomized, double blind, pragmatic trial among patients with acute coronary syndrome or stable coronary ...
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-10)
Red cell distribution width (RDW), a measure of variability in size of circulating
erythrocytes, is associated with arterial cardiovascular disease (CVD), but the
underlying mechanism remains unclear. We aimed to investigate the impact of
chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this
relationship, and explore whether RDW could be a mediator in the causal pathway
between ...
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but
conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
Background: The American Heart Association has proposed an impact goal for the year 2020 to improve
cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed
cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact
fraction (GIF).
<p>Methods: The health metric score was derived from ideal ...
Maternal functional hemodynamics in the second half of pregnancy: A longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-10)
Objective: Cardiovascular response to passive leg raising (PLR) is useful in assessing preload
reserve, but it has not been studied longitudinally during pregnancy. We aimed to investigate
gestational age associated serial changes in maternal functional hemodynamics and
establish longitudinal reference ranges for the second half of pregnancy. Materials and Methods:
This was a prospective ...