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Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine ...
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Many incident cases of type 2 diabetes do not
fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic
score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and ...
Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-22)
BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND ...
Obesity measures and risk of venous thromboembolism and myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Red Cell Distribution Width Is Associated With Incident Myocardial Infarction in a General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Venous thromboembolism increases the risk of atrial fibrillation: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Physical activity and risk of venous thromboembolism. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single
nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the
rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is
causal, one could also expect rs4704397 genotypes to predict CVD and possibly ...
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects,
we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist
circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up
(additional 137,052 individuals) in a total ...