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Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Repeated assessments of physical activity and risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
<p><i>Background</i>: Whether physical activity influences the risk of incident venous thromboembolism (VTE) remains controversial, potentially because of methodological challenges, such as regression dilution bias.</p>
<p><i>Objectives</i>: To investigate whether physical activity was associated with VTE risk, and explore the role of body mass index (BMI) as a mediator in a population‐based ...
C-reactive protein and risk of venous thromboembolism: Results from a population-based case-crossover study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
Long-term, low-grade inflammation does not seem to be a risk factor for venous thromboembolism. The impact of acute inflammation, regardless of cause, on risk of venous thromboembolism is scarcely studied. We aimed to investigate the impact of acute inflammation, assessed by C-reactive protein, on short-term risk of venous thromboembolism. We conducted a case-crossover study of patients with venous ...
Hematocrit and risk of venous thromboembolism in a general population. The Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
Repeated measurements of carotid atherosclerosis and future risk of venous thromboembolism: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-05)
<p><i>Background</i>: Whether a relationship between atherosclerosis and subsequent venous thromboembolism (VTE) exists is controversial.</p>
<p><i>Objective</i>: To investigate the association between carotid atherosclerosis and VTE by using repeated measurements of intima media thickness (IMT) and total plaque area (TPA) in participants recruited from the general population.</p>
<p><i>Methods</i>: ...
Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09)
Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and these two F5 variants on venous thromboembolism risk in a case-cohort study. Cases with a first venous ...
Myocardial infarction and future risk of cancer in the general population—the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)
The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditions and in response to androgens. In silico studies allowed the selection of 4 miRNAs ...
Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)
The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely investigated. The aim of the study was to investigate if incidence rates (IRs) of VTE differed in patients who were alive at least 2 years after a cancer diagnosis without VTE ...
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to investigate (1) whether plasma complement component C5 (C5) levels are influenced by genetic variants or chronic inflammation and (2) the association between plasma C5 and risk of future VTE in a nested case-control study of 415 patients with VTE and 848 age- and sex-matched controls derived from the ...