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Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Background:<br>Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.<br>Methods:<br>In a European ...
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-12)
<p><i>Background - </i>Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.
<p><i>Methods - </i>We did a combined analysis of ...
Use of repeated blood pressure and cholesterol measurements to improve cardiovascular disease risk prediction: an individual-participant-data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-13)
The added value of incorporating information from repeated blood pressure and cholesterol measurements to
predict cardiovascular disease (CVD) risk has not been rigorously assessed. We used data on 191,445 adults from
the Emerging Risk Factors Collaboration (38 cohorts from 17 countries with data encompassing 1962–2014) with
more than 1 million measurements of systolic blood pressure, total ...
No additional long-term effect of group vs individual family intervention in the treatment of childhood obesity - A randomised trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)
<i>Aim</i>
- Long‐term evaluations of childhood obesity treatments are needed. We examined changes in weight and cardiometabolic risk 1 year after children completed individual family or group‐based weight management interventions.<p><p>
<i>Methods</i>
- In 2009‐2010, 6‐ to 12‐year‐old children with overweight or obesity from Finnmark and Troms (Norway) were recruited after media coverage and ...
Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-17)
Objective To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.<p>
<p>Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.
<p>Setting General population.
<p>P ...
Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-28)
Many incident cases of type 2 diabetes do not
fulfil the metabolic syndrome, which accordingly has been
questioned both as a research and clinical tool. The aim of
this study was to determine differences in risk factors for
type 2 diabetes between groups with high or low metabolic
score. The study population were 26,093 men and women
attending the Tromsø Study in 1994, followed through
2005, ...
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Genome-wide association studies (GWAS) have identified ~ 100 loci associated with blood lipid levels, but much of the trait
heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We
conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with
triglycerides (TG), high-density ...