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Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-27)
Background: Results from several cohort and case–control studies suggest a protective association between current alcohol
intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain
unanswered.<p>
<p>Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid
carcinoma ...
Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-14)
Tumor–host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of
malignant cells to hijack and exploit the normal physiological processes of the host. Here, we established that many genes
within peripheral blood cells show differential expression when an untreated breast cancer (BC) is present, and harnessed
this fact to construct a 50-gene ...
Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)
Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective
Investigation into ...
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-11)
<p>Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated.
<p>Methods: A SEM, at a given CpG site, was defined as an extreme ...
Physical activity patterns and the risk of colorectal cancer in the Norwegian Women and Cancer study: A population-based prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-04)
<p><I>Introduction</I>: Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in men, while results of studies in women have been largely equivocal. We aimed to further examine the relationship between PA patterns and the risk of CRC in women, using ...
Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-13)
The majority of lung cancer is caused by tobacco smoking, and lung cancer-relevant epigenetic markers have been identified in relation to smoking exposure. Still, smoking-related markers appear to mediate little of the effect of smoking on lung cancer. Thus in order to identify disease-relevant markers and enhance our understanding of pathways, a wide search is warranted. Through an epigenome-wide ...
Heterogeneity of Associations between Total and Types of Fish Intake and the Incidence of Type 2 Diabetes: Federated Meta-Analysis of 28 Prospective Studies Including 956,122 Participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-07)
The association between fish consumption and new-onset type 2 diabetes is inconsistent and differs according to geographical location. We examined the association between the total and types of fish consumption and type 2 diabetes using individual participant data from 28 prospective cohort studies from the Americas (6), Europe (15), the Western Pacific (6), and the Eastern Mediterranean (1) comprising ...
Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
<i>Background</i>
- Concerns have been raised that extensive use of personal care products that contain endocrine disrupting compounds increase the risk of hormone sensitive cancers.<p>
<p><i>Objective</i>
- To assess the effect of skincare product use on the risk of pre- and postmenopausal breast cancer, estrogen receptor positive (ER+) and negative (ER-) breast cancer and cancer of the ...
Each pregnancy linearly changes immune gene expression in the blood of healthy women compared with breast cancer patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
<p><i>Background</i>: There is a large body of evidence demonstrating long-lasting protective effect of each full-term pregnancy (FTP) on the development of breast cancer (BC) later in life, a phenomenon that could be related to both hormonal and immunological changes during pregnancies. In this work, we studied the pregnancy-associated differences in peripheral blood gene expression profiles between ...