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Evidence for a direct harmful effect of alcohol on myocardial health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest Russia, 2015 to 2017
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
<i>Background</i> - Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation.<p><p>
<i>Methods and Results</i> - The Know Your ...
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-08)
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, ...
Sex-Specific Associations between Blood Pressure and Risk of Atrial Fibrillation Subtypes in the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-05)
The aim of this study was to explore sex-specific associations between systolic blood pressure (SBP), hypertension, and the risk of incident atrial fibrillation (AF) subtypes, including paroxysmal, persistent, and permanent AF, in a general population. A total of 13,137 women and 11,667 men who participated in the fourth survey of the Tromsø Study (1994–1995) were followed up for incident AF until ...
Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-14)
<p>Background: Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with ...
Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
PURPOSE - It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment.<p>
<p>PATIENTS AND METHODS - Based on the Cancer Registry of Norway, ...
Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
Introduction: Alcohol consumption may promote aromatization of androgens to estrogens, which may partly
explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is
associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women
remains unclear.<p>
<p>Methods: Alcohol consumption was collected by self-report ...
Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-14)
Aim: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study.<p>
<p>Method: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as the gold standard, we calculated correctness (defined as positive predictive value, PPV) and ...
Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)
Objective To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures.<p>
<p>Design Individual participant meta-analysis using data from 25 cohorts ...
Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)
Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The Norwegian Coronary Stent Trial study is the first to randomize lesions to percutaneous coronary ...
Resting heart rate trajectories and myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-25)
Background: <br>Resting heart rate (RHR) is an established risk factor for cardiovascular disease (CVD),
but long-term individual RHR trajectories and their effect on CVD morbidity and mortality have not
yet been described. <br>
Methods: <br>This large population-based longitudinal study included 14,208 men and women aged 20
years or older, not pregnant, and not using blood pressure medications, ...