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Suffering, agency and care in medically unexplained symptoms (MUS). An ethnographic study of the social course and reframing of MUS in Norwegian youth
(Doctoral thesis; Doktorgradsavhandling, 2020-05-12)
Communicative challenges and the role of communication in making sense of symptoms are shown in the scientific and biomedical conceptualizations of the phenomenon of medically unexplained symptoms (MUS), in health communication and in the challenges of patients with MUS to understand and manage their illnesses. Little is known about young people’s experiences, how they cope with their illness and ...
TRIM proteins in autophagy: A study of TRIM32 and TRIM27
(Doctoral thesis; Doktorgradsavhandling, 2020-02-02)
<p>TRIM proteins are ubiquitin E3 ligases known to be involved in a number of different processes in the cells, such as intracellular signaling, transcription, autophagy, innate immunity, cell cycle progression and DNA repair. Mutations and dysregulation of TRIM proteins are implicated in many diseases, and a number of TRIMs are described as both tumor suppressors and oncogenes. Furthermore, several ...
Triggers and risk factors of first and recurrent venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2020-01-29)
Venous thromboembolism (VTE), encompassing both deep vein thrombosis and pulmonary embolism, is a major public health concern due to substantial morbidity and mortality. Around half of all VTE cases are hospital-related. Importantly, VTE also has life-long implications, as a large proportion of VTE-patients suffer either a recurrent event or chronic complications. The first aim of the thesis was to ...
Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy
(Doctoral thesis; Doktorgradsavhandling, 2020-02-20)
Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...
Dental anxiety in adolescents and adults. Epidemiological studies based on the Tromsø Study 7 and Fit Futures 1 & 2
(Doctoral thesis; Doktorgradsavhandling, 2021-10-01)
<p><i>Background:</i> High dental anxiety can hinder individuals from seeking necessary dental treatment and thereby an obstacle in ensuring equal access to health care in the population. The overall aim of this thesis was to advance the understanding of dental anxiety in adolescents and adults, with a focus on the relevance of mental health symptoms, oral health and potentially traumatic events. ...
The temporal development of cognitive behavioral therapy as treatment for unipolar depression. An evaluation based on three meta-analyses, focusing on time-trends, effect sizes, and associated moderators
(Doctoral thesis; Doktorgradsavhandling, 2021-11-29)
The present thesis` main objective was to examine time-trends related to CBT as an anti-depressive treatment. A meta-analytic approach was the tool for such investigations, in which the formats of individual, group (GCBT), and mindfulness-based cognitive behavioral therapy (MCBT) were explored from a temporal point of view, and the results subsequently summarized in four articles. The meta-analyses ...
Advanced methods in reproductive medicine: Application of optical nanoscopy, artificial intelligence-assisted quantitative phase microscopy and mitochondrial DNA copy numbers to assess human sperm cells
(Doctoral thesis; Doktorgradsavhandling, 2021-10-22)
Declined fertility rate and population is a matter of serious concern, especially in the developed nations. Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF), have provided great hope for infertility treatment and maintaining population growth and social structure. With the help of ART, more than 8 million babies have already been born so far. Despite the worldwide ...
Shaping the Perception of Risk: Investigating a Paradigmatic Case of Applied Decision Making under Uncertainty
(Doctoral thesis; Doktorgradsavhandling, 2021-12-15)
Risk and uncertainty characterise most human endeavours. Whether judging risk when buying a house, making a career change, considering marriage, or simply ordering food at an unfamiliar restaurant, each decision involves evaluating the available evidence to infer the likelihood of negative outcomes. Such decisions are often marked by uncertainty, the condition of incomplete knowledge about the ...
Mechanism and structural requirements for formation of p62 bodies and degradation of p62 by selective autophagy
(Doctoral thesis; Doktorgradsavhandling, 2021-12-03)
Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress. For the autophagic process to be precise, selective autophagy receptors (SARs) like SQSTM1/p62 are required.
Autophagic substrates ...
Medication therapy and treatment goal achievement among persons with coronary heart disease in a general population - Guideline adherence, medication adherence and validation of medication use
(Doctoral thesis; Doktorgradsavhandling, 2021-12-13)
<p><i>Aim -</i> To assess the adherence to medication therapy for secondary prevention and achievement of treatment goals in persons with coronary heart disease (CHD) in a general population.
<p><i>Methods -</i> This project used data from the seventh wave of the Tromsø Study, alone and linked with data from the Norwegian Prescription database (NorPD). Participants self-reporting CHD were included ...