• Age-dependent effects of protein restriction on dopamine release 

      Naneix, Fabien; Peters, Kate Z.; Young, Andrew J.; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-31)
      Despite the essential role of protein intake for health and development, very little is known about the impact of protein restriction on neurobiological functions, especially at different stages of the lifespan. The dopamine system is a central actor in the integration of food-related processes and is influenced by physiological state and food-related signals. Moreover, it is highly sensitive to ...
    • Investigating the effect of physiological need states on palatability and motivation using microstructural analysis of licking 

      Naneix, Fabien; Peters, Kate; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-01)
      The study of consummatory responses during food intake represents a unique opportunity to investigate the physiological, psychological and neurobiological processes that control ingestive behavior. Recording the occurrence and temporal organization of individual licks across consumption, also called lickometry, yields a rich data set that can be analyzed to dissect consummatory responses into different ...
    • No evidence that portion size influences food consumption in male Sprague Dawley rats 

      Naneix, Fabien; Pinder, Sophie C.; Summers, Megan Y.; Rouleau, Renee M.; Robinson, Eric; Myers, Kevin P.; McCutcheon, James E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-18)
      In studies of eating behavior that have been conducted in humans, the tendency to consume more when given larger portions of food, known as the portion size effect (PSE), is one of the most robust and widely replicated findings. Despite this, the mechanisms that underpin it are still unknown. In particular, it is unclear whether the PSE arises from higher-order social and cognitive processes that ...
    • Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity 

      Chiacchierini, Giulia; Naneix, Fabien; Peters, Kate Z; Aspergis-Schoute, John; Snoeren, Eelke; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Control of protein intake is essential for numerous biological processes as several amino acids cannot be synthesized de novo, however, its neurobiological substrates are still poorly understood. In the present study, we combined in vivo fiber photometry with nutrient-conditioned flavor in a rat model of protein appetite to record neuronal activity in the VTA, a central brain region for the control ...
    • Restriction of dietary protein in rats increases progressive-ratio motivation for protein 

      Chiacchierini, Giulia; Naneix, Fabien; Apergis-Schoute, John; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-29)
      Low-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task – the progressive ratio test – to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (REST, 5% protein diet) compared to non-restricted control rats (CON, 18% protein). ...