• Female rat sexual behavior is unaffected by perinatal fluoxetine exposure 

      Hegstad, Jan; Huijgens, Patty Thalia; Houwing, Danielle; Olivier, Jocelien; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)
      Serotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on sexual functioning in adulthood. During early development, serotonin acts as neurotrophic factor, while it functions as a modulatory neurotransmitter in adulthood. The occurrence of serotonin release, could thus have different effects on behavioral ...
    • Male rat sexual behavior: Insights from inter-copulatory intervals 

      Huijgens, Patty Thalia; Guarraci, Fay; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-09)
      The assessment of sexual behavior in male rats with the aim of unraveling underlying neurobiological mechanisms has in the recent decades been reduced to the annotation of mounts, intromissions and ejaculations. To provide a better understanding of the structure and patterns of copulation, it is necessary to extend and tailor the analysis to the natural organization of male rat copulation. This will ...
    • Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment 

      Houwing, Danielle; Heijkoop, Roy; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
      The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes ...
    • Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure 

      Heinla, Indrek; Heijkoop, Roy; Houwing, Danielle; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-26)
      SSRIs are commonly used to treat pregnant women with depression. However, SSRIs can cross the placenta and affect the development of the fetus. The effects of perinatal SSRI exposure, and especially the effects on social behavior, are still incompletely documented. This study first aims to investigate whether rats show prosocial behavior in the form of consolation behavior. Secondly, it aims to ...