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In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
<i>Background:</i> In the care of persons with cognitive problems, it is important to use a valid mild cognitive impairment (MCI) criterion that discriminates well between normal and pathological aging.<p>
<p><i>Objective:</i> To find the brief neuropsychological screening criterion that best correlates with cerebrospinal fluid (CSF) biomarkers for cognitive decline and dementia in persons ...
Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-10)
<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving
enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ)
clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in
Alzheimer’s disease.<p>
<p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective ...
Regression-based norms for the FAS phonemic fluency test for ages 40–84 based on a Norwegian sample
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-08)
<p>The FAS phonemic fluency test is a commonly used neuropsychological test of executive function and processing speed. Although Norwegian discrete norms have been developed for the FAS test, American regression-based norms are frequently used by clinicians in Norway.
<p>However, language and cultural differences impact performance on the FAS test, and using foreign norms may not be appropriate. ...
Predictive and diagnostic utility of brief neuropsychological assessment in detecting Alzheimer's pathology and progression to dementia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
Objective: To assess the role of brief neuropsychological assessments in prediction and identification of Alzheimer’s disease (AD) pathology and progression to AD dementia. Method: Adults (N = 255; range = 40–81 years) with self-reported cognitive decline underwent baseline and 2-year follow-up clinical assessment, including a brief neuropsychological screening and lumbar puncture. Five different ...
Screening for Alzheimer’s Disease: Cognitive Impairment in Self-Referred and Memory Clinic-Referred Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-07)
<p>Background</i>: Cognitive assessment is essential in tracking disease progression in AD. Presently, cohorts including preclinical
at-risk participants are recruited by different means, which may bias cognitive and clinical features. We compared recruitment
strategies to levels of cognitive functioning.<p>
<p><i>Objective</i>: We investigate recruitment source biases in self-referred and ...
Exploration of plasma lipids in mild cognitive impairment due to Alzheimer's disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-29)
<p><i>Background: </i>Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer’s disease (AD) pathology.
<p><i>Objective:</i> To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology.
<p><i>Methods: </i>We identified ...
Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-13)
To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Beta-site amyloid-precursor-protein cleaving enzyme1 (BACE1), Ng/BACE1 ratio and Amyloid-β 42/40 ratio, phosphorylated-tau and total-tau in LLD with (LLD AD) or ...
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)
Importance Identification of proteins and genetic factors that reduce Alzheimer disease (AD) pathology is of importance when searching for novel AD treatments. Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. Whether this association is mediated by the Klotho protein remains unclear.
Objectives To assess concentrations of Klotho in cerebrospinal ...