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Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-10)
<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving
enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ)
clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in
Alzheimer’s disease.<p>
<p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective ...