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    • α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons 

      Stephens, Amberley D.; Villegas, Ana Fernandez; Chung, Chyi Wei; Vanderpoorten, Oliver; Pinotsi, Dorothea; Mela, Ioanna; Ward, Edward; McCoy, Thomas M.; Cubitt, Robert; Routh, Alexander F.; Kaminski, Clemens F.; Kaminski Schierle, Gabriele S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-15)
      Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson’s disease patient’s brains. Previous work to address pathological aSyn-lipid interactions has focused on using synthetic lipid membranes, which lack the complexity of ...