Recent additions

  • Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin‐proteasome and autophagy‐lysosomal system 

    Franeková, Veronika; Storjord, Hilde, I.; Leivseth, Gunnar; Nilssen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)
    Aims: Limb-girdle muscular dystrophy R9 (LGMDR9) is an autosomal recessive disorder caused by mutations in the fukutin-related protein gene (FKRP), encoding a glycosyltransferase involved in α-dystroglycan modification. Muscle atrophy, a significant feature of LGMDR9, occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin–proteasome system (UPS) ...
  • Combining education and income into a socioeconomic position score for use in studies of health inequalities 

    Lindberg, Marie Hella; Chen, Gang; Olsen, Jan Abel; Abelsen, Birgit (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-13)
    Background: In studies of social inequalities in health, there is no consensus on the best measure of socioeconomic position (SEP). Moreover, subjective indicators are increasingly used to measure SEP. The aim of this paper was to develop a composite score for SEP based on weighted combinations of education and income in estimating subjective SEP, and examine how this score performs in predicting ...
  • Concurrent palliative chemoradiation leads to survival and quality of life benefits in poor prognosis stage III non-small-cell lung cancer: a randomised trial by the Norwegian Lung Cancer Study Group 

    Strøm, Hans Henrik; Bremnes, Roy M.; Sundstrøm, Stein Harald; Helbekkmo, Nina; Fløtten, Øystein; Aasebø, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-08-20)
    Background: The palliative role of chemoradiation in the treatment of patients with locally advanced, inoperable non-small-cell lung cancer stage III and negative prognostic factors remains unresolved.<p> <p>Methods: Patients not eligible for curative radiotherapy were randomised to receive either chemoradiation or chemotherapy alone. Four courses of intravenous carboplatin on day 1 and oral ...
  • Parenting an Adolescent with Severe Emotional Difficulties – A Qualitative Study of Family Experiences with DBT-A 

    Rolandsen, Christina (Master thesis; Mastergradsoppgave, 2021-05-01)
    Parenting an adolescent with severe emotional difficulties is challenging, and research shows that when parents do not receive adequate support it can have adverse consequences for the parents, the adolescents, and their siblings. Dialectical behavioral therapy for adolescents (DBT-A) is a treatment method that has an increased focus on parental support, and by including parents in treatment DBT-A ...
  • Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study 

    Lagiou, Pagona; Sandin, Sven; Löf, Marie; Trichopoulos, Dimitrios; Adami, Hans-Olov; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-06-26)
    Objective To study the long term consequences of low carbohydrate diets, generally characterised by concomitant increases in protein intake, on cardiovascular health.<p> <p>Design Prospective cohort study. <p>Setting Uppsala, Sweden. <p>Participants From a random population sample, 43 396 Swedish women, aged 30-49 years at baseline, completed an extensive dietary questionnaire and were ...
  • The use of iohexol as a marker to measure glomerular filtration rate in the non-steady state of patients undergoing robot-assisted colorectal surgery 

    Jakobsen, Kjellbjørn (Master thesis; Mastergradsoppgave, 2021-05-23)
    Introduction Perioperative acute kidney injury (AKI) is associated with increased morbidity and mortality. Estimated glomerular filtration rate (eGFR) is routinely used to monitor renal function. This is an imprecise tool in the non-steady state condition and much kidney function can be lost before it is detectable by the eGFR method. A continuous low-dose infusion of iohexol has been proposed as ...
  • Hvor nyttige er nye legemiddelbehandlinger egentlig? 

    Moss, Johan Mikkelborg (Mastergradsoppgave; Master thesis, 2021-05-21)
    Introduksjon: Legemidler blir ofte presentert i media som supermedisiner og gir inntrykket av at helseeffekten er enorm. Hvorvidt fremstillingen i media speiler virkeligheten er uklart. Statens legemiddelverk (SLV) metodevurderer legemidler for å undersøke om de er bedre enn nåværende behandling. Metodevurderingene inneholder ofte informasjon om QALY-gevinst. Hensikt: Primærmålet er å undersøke ...
  • Validity of self-reported educational level in the Tromsø Study 

    Vo, Chi Quynh; Samuelsen, Per-Jostein; Sommerseth, Hilde Leikny; Wisløff, Torbjørn; Wilsgaard, Tom; Eggen, Anne Elise (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-20)
    Background: Self-reported data on educational level have been collected for decades in the Tromsø Study, but their validity has yet to be established. Aim: To investigate the completeness and correctness of self-reported educational level in the Tromsø Study, using data from Statistics Norway. In addition, we explored the consequence of using these two data sources on educational trends in ...
  • Abstracts from The Cold Weather Operations Conference 2021 

    Norheim, Arne Johan; Rannestad, Bård Stian; Howes, Richard; Rein, Erling Bekkestad; Jørum, Ellen; Friedl, Karl; Havenith, George; Teien, Hilde Kristin; Mercer, James; Melau, Jørgen; de Weerd, Louis; Smith, Michael; Taylor, Natalie; Voie, Øyvind Albert; Bergan-Skar, Pål; Andrews, Steve; Næsheim, Torvind; Steinberg, Tuva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-11)
    A common effort for both military and civil healthcare is to achieve knowledge-based health care in cold weather injuries and fatal accidents in harsh arctic environment. The Cold Weather Operations Conference in November 2021, having more than 300 participants from 20 countries, was addressing the prevention and treatment of injuries and trauma care in cold weather conditions and the challenges for ...
  • Vitamin D: Relations with Sleep and Bone Mineral Density. Insights from the Tromsø Study and randomized controlled trials 

    Larsen, Anette Uhlving (Doctoral thesis; Doktorgradsavhandling, 2022-06-10)
    In this thesis, the relationship between vitamin D and health-related outcomes has been investigated. More than 21,000 individuals participated in the Tromsø Study 2015-16. The participants donated blood samples and filled in questionnaires regarding their health status, including questions about their sleep health. Using these data, the association between vitamin D and sleep duration, daytime ...
  • Integrating mental health into primary care in Arkhangelsk County, Russia: the Pomor model in psychiatry 

    Rezvyy, Grigory; Andreeva, Elena; Ryzhkova, Nadezhda; Yashkovich, Vera; Sørlie, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)
    Background: Primary health care is still peripheral in the identifcation and treatment of mental health and substance use disorders in the Russian Federation. However, the development of primary health services has been given priority. A long-standing collaboration between Arkhangelsk County and northern Norway on mental health service development in Arkhangelsk has promoted the integration of ...
  • Influence of professionally assessed normative orthodontic treatment need on adult OHRQoL 

    Dahlberg, Magne A.; Konradsen, Anders (Master thesis; Mastergradsoppgave, 2021-05-20)
    Introduction: There is an increasing amount of research regarding the impact of malocclusions on OHRQoL. Reviews on this topic has mostly focused on children and adolescents, and therefore the aim of this thesis is to investigate the impact of professionally assessed normative orthodontic treatment need on adult OHRQOL. Materials and methods: Four electronic databases (PubMed, EMBASE, Cochrane ...
  • Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months 

    Jorde, Rolf; Svartberg, Johan; Joakimsen, Ragnar Martin; Coucheron, Dag-Hugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-05-17)
    Background: Recently a large number of short non-coding-RNAs (microRNAs, (miRNA)) have been identified. These miRNAs act as post-transcriptional regulators where they generally have an inhibitory function. miRNAs are present in all human cells, and they are also detected in serum or plasma. The miRNAs have a broad range of actions, and their biogenesis must therefore be under tight control. One ...
  • Overdiagnosis in screening mammography in Denmark: population based cohort study 

    Njor, Sissel Helle; Olsen, Anne Helene; Blichert-Toft, Mogens; Schwartz, Walter; Vejborg, Ilse; Lynge, Elsebeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-02-26)
    Objective To use data from two longstanding, population based screening programmes to study overdiagnosis in screening mammography.<p> <p>Design Population based cohort study. <p>Setting Copenhagen municipality (from 1991) and Funen County (from 1993), Denmark. <p>Participants 57 763 women targeted by organised screening, aged 56-69 when the screening programmes started, and followed up to ...
  • Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition 

    Romieu, Isabelle; Scoccianti, Chiara; Chajès, Véronique; De Batlle, Jordi; Biessy, Carine; Dossus, Laure; Baglietto, Laura; Clavel-Chapelon, Françoise; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Kaaks, Rudolf; Lukanova, Annekatrin; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; van Gils, Carla H.; Peeters, Petra H.; Lund, Eiliv; Skeie, Guri; Weiderpass, Elisabete; García, José Ramón Quirós; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sánchez, María-José; Duell, Eric J.; Amiano, Pilar; Borgquist, Signe; Wirfält, Elisabet; Hallmans, Göran; Johansson, Ingegerd; Nilsson, Lena Maria; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Travis, Ruth C.; Murphy, Neil; Wark, Petra A.; Ferrari, Pietro; Riboli, Elio (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)
    Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into ...
  • Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations 

    Gabrielsen, Mari; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-14)
    The serotonin (5-HT) transporter (SERT) plays an important role in the termination of 5-HT-mediated neurotransmission by transporting 5-HT away from the synaptic cleft and into the presynaptic neuron. In addition, SERT is the main target for antidepressant drugs, including the selective serotonin reuptake inhibitors (SSRIs). The three-dimensional (3D) structure of SERT has not yet been determined, ...
  • Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment 

    Sylte, Ole Christian; Johansen, Jesper Solheim; Heinla, Indrek; Houwing, Danielle; Olivier, Jocelien D.A.; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
    Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various afective disorders during pregnancy. SSRIs cross the placenta and afect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the ofspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social ...
  • Dietary intake and changes in relation to BMI SDS and metabolic measures in a childhood obesity intervention – Finnmark Activity School 

    Berglund, Thea (Master thesis; Mastergradsoppgave, 2021-05-16)
    Background: Overweight and obesity in childhood doubles the risk of becoming overweight as an adult, as well as it increases the risk of related comorbidities. Cardiovascular diseases are a consequence of obesity and the most common cause of death worldwide. Diet and physical activity are modifiable causes of overweight. Overweight and obesity should be prevented, but treatment must be optimized as ...
  • Liposomal formulations for membrane active antimicrobials – Assuring safety through an optimised drug delivery system 

    Pettersen, Ann Kristin (Master thesis; Mastergradsoppgave, 2020-05-13)
    Skin and soft tissue infections (SSTIs) and chronic wounds are major challenges for the healthcare system worldwide. The additional rapid development of antibacterial resistance and lack of successful treatment strategies increase the chance for infected chronic wounds to be fatal for the patient. Therefore, there is a need for more efficient dermal antimicrobial therapies. A class of promising ...
  • Fysisk aktivitet, maksimalt oksygenopptak og diabetes type 2. En tverrsnittstudie basert på Aktivitetsstudien – en del av Tromsøundersøkelsen 

    Hoel, Einar Jøraholmen (Master thesis; Mastergradsoppgave, 2021-05-13)
    Bakgrunn: Prevalensen av diabetes type 2 er økende globalt. Det er kjent at fysisk aktivitet og fysisk form (VO2maks) har en rekke positive helseeffekter, deriblant forhindre eller forsinke utviklingen av diabetes type 2. Det er imidlertid lite forskning på sammenhengen mellom objektivt målt fysisk aktivitetsnivå, fysisk form og risiko for å utvikle diabetes type 2 blant friske voksne mennesker. ...

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